Mycobacterium research and diagnosis

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Polyketide synthase 12 is an in vivo essential source of novel mycolyl lipids in Mycobacterium tuberculosis
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.25.754250
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Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach.
eLife · 23 Sept 2026 · Journal Article
Semapimod inhibits L-leucine uptake in Mycobacterium tuberculosis, reducing bacterial load in infected mice despite no in vitro efficacy.
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https://jclub.com.au/a/42775406
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Gene conversion is a key driver of diversity hotspots in M. tuberculosis antigens and virulence-associated loci
bioRxiv · 22 Sept 2026 · Preprint
Gene conversion drives over 300 diversity hotspots in M. tuberculosis, especially within virulence and antigen-related gene families, increasing genetic variation by more than tenfold.
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https://jclub.com.au/a/10.64898/2026.02.26.708061
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Tobramycin enhances Mycobacterium abscessus fitness through whiB7 induction.
Proceedings of the National Academy of Sciences · 22 Sept 2026 · Journal Article
Tobramycin increases Mycobacterium abscessus survival by inducing whiB7, promoting persistent infection in cystic fibrosis airway conditions.
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https://jclub.com.au/a/42752235
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Migration and tuberculosis transmission in Hamburg, Germany: insights from 25 years of molecular epidemiology.
Genome Medicine · 17 Sept 2026 · Journal Article
Migration increases the genetic diversity of Mycobacterium tuberculosis complex strains in Hamburg but does not change local transmission patterns, which remain lineage-specific.
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https://jclub.com.au/a/42768361
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Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.26.678883
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β-Lactam antibiotics trigger mouse TLR2/4- and human TLR2/5-dependent Jarisch-Herxheimer reaction in leptospirosis
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.29.721589
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A state-structured pharmacodynamic framework separating resistance, tolerance and persistence, applied to Mycobacterium tuberculosis and Staphylococcus aureus
bioRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.02.12.637810
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Transition of Staphylococcus aureus tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 years
bioRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.14.675889
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Autodissemination stations suppress Aedes notoscriptus mosquitoes and reduce Buruli ulcer risk in urban Australia: a randomized controlled field trial.
Nature Microbiology · 1 Sept 2026 · Randomized Controlled Trial
Autodissemination stations reduce Aedes notoscriptus mosquito populations by 70% and lower Buruli ulcer cases by 83% in urban Melbourne, Australia.
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https://jclub.com.au/a/42661072
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