Chronic Lymphocytic Leukemia Research

Moving in Blood, Gastroenterology, bioRxiv, medRxiv and Nature Communications.

Moved, week to 23 Oct 2026: 0
Papers in 60 days: 10

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Latest in Chronic Lymphocytic Leukemia Research

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BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.
bioRxiv · 17 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.07.723540
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PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12.
Nature Communications · 9 Oct 2026 · Journal Article
Roginolisib selectively inhibits PI3Kδ by stabilizing the C-terminal helix kα12, locking the enzyme in an inactive conformation.
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https://jclub.com.au/a/42855469
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Lipoprotein remodelling and elevated serum apolipoprotein B distinguish adults with haemophagocytic lymphohistiocytosis from sepsis
medRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.13.26352642
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Therapeutic targeting of IL-17A-driven PTGS2/NLRP3 inflammasome activation in juvenile myelomonocytic leukemia.
Blood · 17 Sept 2026 · Journal Article
In PTPN11-mutant juvenile myelomonocytic leukemia, dual NLRP3 and PTGS2 inhibition combined with MEK blockade significantly prolongs survival and reduces leukemic burden in models.
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https://jclub.com.au/a/42233403
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First-line ibrutinib plus venetoclax for MCL.
Blood · 17 Sept 2026 · Journal Article
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https://jclub.com.au/a/42752832
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Five-year survival outcomes of lisocabtagene maraleucel in R/R LBCL from the TRANSCEND NHL 001 study.
Blood · 10 Sept 2026 · Clinical Trial, Phase I
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https://jclub.com.au/a/42237652
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IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas.
Blood · 3 Sept 2026 · Journal Article
IL-16-driven signaling mediates resistance to BTK inhibitors and R-CHOP in B-cell lymphomas, with IL-16 upregulation observed in resistant cases.
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https://jclub.com.au/a/42213644
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Effectiveness of Risankizumab After Ustekinumab Failure in Crohn's Disease: A Multicenter Retrospective Cohort Study.
Gastroenterology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42107795
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Primary Immunodeficiencies Masquerading as Inflammatory Bowel Diseases.
Gastroenterology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/41935724
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Ibrutinib for early-stage CLL: genetic risk factors and treatment outcome in the GCLLSG CLL12 trial.
Blood · 27 Aug 2026 · Clinical Trial, Phase III
Ibrutinib improves event-free survival in early-stage CLL patients with certain genetic mutations but offers no overall survival benefit across all subgroups.
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https://jclub.com.au/a/42322115
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