Early vasopressor therapy with restricted fluids in septic shock does not increase days alive and out of hospital at 90 days compared to higher-volume fluids with later vasopressors.
Trauma, Hemostasis, Coagulopathy, Resuscitation
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The spleen filters activated platelets to prevent thrombosis and inflammation, maintaining systemic platelet quiescence and reducing thrombo-inflammatory risk in mice.
Balanced crystalloid fluid does not significantly reduce adverse kidney events compared to 0.9% saline in children with septic shock, with event rates of 3.4% versus 3.0%.
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