A spatial atlas of muscle-invasive bladder cancer shows a continuous luminal-to-basal axis linked to chromosomal instability and transcriptional plasticity in individual tumors.
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Bladder and Urothelial Cancer Treatments
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[18F]RCCB6 PET/CT achieves 94.2% sensitivity in detecting metastases in clear-cell renal cell carcinoma, outperforming [18F]FDG PET/CT and conventional imaging.
Metastasis-to-metastasis seeding dominates bladder cancer spread, with heterogeneity and early driver alterations linked to poor prognosis in specific subtypes.
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HSPA6 promotes lenvatinib resistance in hepatocellular carcinoma by stabilizing TXNRD1 through phase separation, reducing ferroptosis, and correlating with poor patient outcomes.
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