Obinutuzumab significantly improves disease activity in adults with active systemic lupus erythematosus, achieving a 23.1 percentage point higher response rate than placebo at week 52.
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Systemic Lupus Erythematosus Research
Moving in New England Journal of Medicine.
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Geranylgeranyltransferase type II (GGTase II) is essential for B-cell activation, proliferation, and plasma cell survival, with its inhibition reducing autoimmune disease activity in mice.
Single-cell genomics has identified pathogenic lymphocyte, myeloid, and fibroblast cell subsets in immune-mediated rheumatoid arthritis.
Alterations in glycolysis, mitochondrial function, and mTOR signaling in lymphocytes are linked to the development of T-cell-mediated autoimmunity in diseases like MS, RA, and T1D.
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- Nature151
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- Lancet128
- Cell Rep127
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3