Lymphoma Diagnosis and Treatment

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BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.27.672737
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A single-cell atlas identifies oncogenic transcriptional programs and immune escape mechanisms in CTCL.
Blood · 1 Oct 2026 · Journal Article
A single-cell RNA-sequencing atlas of over 2 million cells from 116 CTCL patients reveals recurrent oncogenic transcriptional programs and immune escape mechanisms.
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https://jclub.com.au/a/42378251
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Venetoclax plus pediatric regimen in adolescents and adults with Ph-negative acute lymphoblastic leukemia.
Blood · 24 Sept 2026 · Clinical Trial, Phase II
Venetoclax combined with pediatric-inspired chemotherapy achieves a 91% remission rate and improves survival in adolescents and adults with newly diagnosed Ph-negative ALL.
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https://jclub.com.au/a/42166560
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DOT1L shapes ncPRC1 target gene repression to maintain germinal center B-cell identity in diffuse large B-cell lymphoma.
Blood · 24 Sept 2026 · Journal Article
DOT1L regulates ncPRC1 complexes and H2AK119ub1 to sustain germinal center B cell identity in diffuse large B cell lymphoma, with 20 key gene targets identified.
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https://jclub.com.au/a/42213647
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CXCR6+ T cells are required for CD3xCD20 Bispecific Antibody Efficacy in B cell Lymphomas
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.07.02.24309792
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The chaos of choice in large B-cell lymphoma: a call to harmonize first-line trials.
Blood · 24 Sept 2026 · Journal Article
Harmonizing trial design and biomarker integration is essential to improve personalized treatment for large B-cell lymphoma patients.
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https://jclub.com.au/a/42406743
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A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes.
Blood · 17 Sept 2026 · Journal Article
Five conserved malignant B cell archetypes, including a quiescent memory B cell-like type, predict clinical outcomes in large B cell lymphomas, with Archetype 4 linked to poor survival.
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https://jclub.com.au/a/42752800
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Five-year survival outcomes of lisocabtagene maraleucel in R/R LBCL from the TRANSCEND NHL 001 study.
Blood · 10 Sept 2026 · Clinical Trial, Phase I
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https://jclub.com.au/a/42237652
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IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas.
Blood · 3 Sept 2026 · Journal Article
IL-16-driven signaling mediates resistance to BTK inhibitors and R-CHOP in B-cell lymphomas, with IL-16 upregulation observed in resistant cases.
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https://jclub.com.au/a/42213644
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A lipid-laden macrophage niche drives immunosuppression in primary central nervous system lymphoma
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.19.705289
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