STAT3 functions as an inflammation-dependent transcriptional switch in antiviral NK cells, with its activity varying based on IL-15 or type I interferon signals during MCMV infection.
Science Immunology
American Association for the Advancement of Science · Immunology & Inflammation · ISSN 2470-9468
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Glycome remodeling of γδ T cells, specifically loss of branched N-glycans, programs pathogenic IL-17A responses linked to severe psoriasis.
Tuft cells in Peyer's patches' follicle-associated epithelium amplify type 2 immunity and IgA production through IL-25 and IL-13 signaling.
B1-like innate B cells are present in adult human organs in homeostasis, expressing murine B1 markers and secreting IgM.
STING activates NF-κB signaling through M1-linked ubiquitin-dependent recruitment of IKKγ and cooperation with TBK1/IKKε via its carboxyl-terminal tail in mammalian cells.
Migratory dermal γδ T cells activated via IL-1R regulate lung immune responses and tissue damage during helminth infection.
RORC-expressing dendritic cells are enriched in malignant ascites and regional lymph node metastases, linking them to advanced human cancers.
Astrocytes use the CD40 pathway to propagate neuroinflammation, indicating their potential as antigen-presenting cells during neuroinflammatory responses.
Nanobodies targeting MR1-5-OP-RU complexes can bind both mouse and human MR1 and inhibit MAIT cell responses, demonstrating bioactivity in vitro and in vivo.
Decidual fibrinoid-associated neutrophils (dFANs) promote invasive placentation through a specific MMP-9-TGF-β axis in first-trimester human pregnancy.
In vitro, human naive B cells can be converted into GCB-like cells that display ongoing AID-dependent somatic hypermutation, recapitulating key features of natural germinal center B cells.
In vivo CRISPR screens reveal that SLC1A5-mediated glutamine metabolism in tumor cells suppresses CD8 T cell responses and impairs immunotherapy efficacy.
AMnESTI reverses age-related decline in lung immunity, enabling complete heterosubtypic protection by influenza vaccines in aged mice.
Tissue mitochondrial activity determines macrophage pool size through regulation of CSF1 availability in oxidative tissues.
Neutrophils adapt their motility via Rho-dependent contractility to navigate confined capillaries, preventing occlusion and maintaining blood flow during inflammation.
Variant-specific B cells in SARS-CoV-2-infected dogs complement existing immune memory, enhancing neutralization of diverse viral variants.
IgG1-expressing plasma cells outcompete IgM cells by enhanced antigen presentation and signaling, leading to greater bone marrow longevity and immune response efficiency.
Platelet-derived serotonin causes age-related lung damage in SARS-CoV-2 infection, with 50% reduction in respiratory failure when blocked in mice.
Type I IFN-induced IFN-γ primes monocytes to provide systemic bacterial protection during intestinal helminth infections, revealing a novel immune pathway.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3