Soluble vimentin interacts with keratin 6A filaments to promote signaling in epithelial cells, especially during skin wound healing and cancer development.
Genes & Development
Cold Spring Harbor Laboratory Press · Genomics & Bioinformatics · ISSN 0890-9369, 1549-5477
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Early neurodegeneration in Parkinson's disease may be an adaptive transmissive dormancy of dopaminergic neurons, not a sign of dysfunction, with active silencing of neurotransmission.
CEH-43/DLX drives convergent astrocyte-like glia differentiation in C. elegans by regulating axon guidance and synaptic gene expression programs.
Honeybadger, a micropeptide encoded by the 3'- PVT1 segment, binds KRAS and inhibits RAS-MAPK signaling in MYC-driven tumors.
Interactions between cancer cells and adipocytes create a dynamic cross-talk that promotes cancer progression through metabolic mechanisms.
Firefox, a protein encoded by circular PVT1, is essential for MYC-driven oncogenesis, as its depletion reduces MYC protein levels and tumor growth in models.
MEIOSIN independently activates meiotic genes across vertebrates, including species lacking STRA8, by retaining an HMG domain essential for this function.
Lysosomal metabolism in pancreatic ductal adenocarcinoma (PDAC) is essential for tumor survival and interacts with host physiology, but clinical targeting remains challenging.
Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs, with mutants being embryonic lethal.
Mute prevents histone mRNA accumulation outside of S phase by antagonizing Mxc phosphorylation, revealing a novel cell cycle-dependent regulation mechanism.
Disruption of 5'ETS cleavage in pre-rRNA processing causes significant changes in nucleolar structure and organization in eukaryotic cells.
Drosophila Mute represses histone mRNA outside S phase and differentially promotes expression of specific histone genes during S phase.
Temporal gating of mRNA biogenesis determines nuclear export of stress-induced transcripts in human cells, with early transcripts exported before export inhibition during stress.
Nuclear type I myosins are essential for maintaining nuclear and nucleolar structure and function, with depletion causing genome disorganization and nucleolar disruption.
Human PIF1 primarily functions as a DNA translocase that couples unwinding with rapid rewinding to clear secondary DNA structures, with only weak net unwinding observed.
Loss of p53 in mouse embryonic stem cells triggers germline programs, chromatin changes, and metabolic shifts within 48 hours.
Maternally methylated Mest gDMR regulates Klf14 imprinting through allele-specific TAD structures in embryonic stem cells.
Drosophila Scm self-assembles into PcG bodies to recruit PRC2.1, facilitating H3K27me3 domain formation during Polycomb silencing initiation.
The hnRNPA1 D262V mutation in ALS is linked to significant mitochondrial dysfunction and fragmentation in mutant cells.
Cardiac lymphatics regulate embryonic heart growth through a Reelin-dependent epicardial signaling pathway, influencing organ size during development.
Sharp cell type boundaries in hair follicle dermal condensates emerge from coordinated Wnt and Hedgehog signaling, producing a distinct boundary despite continuous morphogen gradients.
MutLα activates methylpurine DNA glycosylase to promote alkylation damage cytotoxicity, revealing a new cross-talk between mismatch repair and base excision repair.
A conserved regulatory helix in HUWE1 acts as an autoinhibitory gate controlling ASCL1 degradation in small cell lung cancer, with charge-flipping mutations accelerating substrate turnover.
Regulatory circuits linking immune cells, metabolism, and stroma sustain noninfectious granulomas across diverse diseases.
MYC proteins enhance tumor cell resilience by engaging in multiple complexes and binding DNA and RNA, supporting oncogenic gene expression in cancer.
MCM10 and RECQL4 cooperatively and redundantly activate the CMG helicase during human DNA replication initiation, with severe defects observed when both are depleted.
Wnt/β-catenin cues are decoded into binary fate decisions in C. elegans through ZIP-7/DBP-mediated transcriptional regulation, enabling embryo-wide patterning.
Maternal small RNAs regulate hybrid compatibility in plants and animals, with incompatibilities affecting 100% of hybrid cases through distinct mechanisms.
Identification of novel germ granule proteins reveals their essential roles in RNAi and small RNA inheritance in Caenorhabditis elegans, with PINT-1 being crucial for siRNA biogenesis.
TNK1 is a JAK-independent kinase that directly activates STAT1, driving inflammation and colitis in mice, revealing a new therapeutic target.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3