Cancer stem cells are highly sensitive to microenvironmental cues and regulate metastasis and therapy response via the YAP/TAZ/TEAD node.
Developmental Cell
Elsevier BV · Cell & Molecular Biology · ISSN 1534-5807, 1878-1551
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Extracellular nitrate-responsive signaling coordinates stress granule assembly and autophagic degradation in cells.
TOLS1, a non-canonical GAP-like protein, is identified as a naturally variable negative regulator of salt tolerance in rice, affecting early calcium signaling.
Cell cycle arrest in the ZL epithelial population is essential for facial prominence fusion in mice and humans, with Zfhx3 deletion initiating orofacial clefting.
SpaceA reveals that mouse embryonic tissue compartments undergo a dramatic shift between E12.5 and E13.5 stages, coinciding with transcriptional transitions.
Human peripheral-central dual neural organoids (hPCOs) reveal bidirectional Wnt signaling roles in neurodevelopment, modeling nociceptor defects and teratogenic risks.
Depletion of SPT5 in Drosophila embryos causes stage-specific shifts in RNA polymerase II positioning, affecting gene regulation during development.
Sustained mechanical stress activates PIEZO1-STAT1-dependent MLKL expression, causing MLKL-dependent membrane-lytic death in cells lacking RIPK3 and canonical phosphorylation.
Long-term confinement induces RIPK3-independent necroptosis in amoeboid cancer cells, with MLKL expression linked to tumor progression and immune response.
Inducible human yolk sac myeloid progenitors (iYSMPs) can differentiate into tissue-specific macrophages, including microglia and Kupffer cells, in vivo.
Natural variation in TOLS1 influences salt tolerance in rice by modulating OsRacB-Ca(2+) signaling, with the TOLS1 A allele exerting a stronger negative effect.
The OsVAL2-OsDOF3-OsCSE module promotes lignin deposition and confers broad-spectrum disease resistance in rice, with ROD1 sequestering OsVAL2 to suppress this immune pathway.
CHL1 + CXCL9 + cancer-associated fibroblasts at lung tumor margins recruit CXCR3 + regulatory T cells, promoting immune evasion in lung cancer.
Developmentally regulated metabolic states, specifically glycolysis and pentose phosphate pathway activity, influence radial glia fate decisions during human corticogenesis.
Nitrate-responsive Sialin2 regulates stress granule dynamics and neuroprotection, with nitrate treatment reducing pathology in an ALS mouse model.
Mitochondrial citrate metabolism drives inflammation independently of mitochondrial DNA signaling but amplifies the inflammatory response in senescent cells.
Synergid cells in flowering plants are essential for guiding pollen tubes and ensuring successful fertilization, with their functions vital for plant fertility.
Postnatal Pax7-expressing limb cells are multipotent and generate non-myogenic lineages, including fibro-adipogenic progenitors, that persist into adulthood, with significant implications for muscle regeneration.
ER-localized transcription factor NAC089 functions as a molecular switch controlling plant cell fate between adaptation and death under stress.
Proteasome activity differences between mouse and human neural progenitors regulate developmental timing, with faster proteasome function in mice accelerating neural differentiation.
Elongating human heart organoids (EHOs) mimic early cardiac morphogenesis, including elongation, looping, and axial organization, with a 50% reduction in length upon TBX5 deletion.
Nodal/Smad2 signaling is essential for maintaining embryonic diapause by repressing Pparg-mediated lipid metabolism, preventing lipid accumulation during dormancy.
Protein turnover rate determines species-specific developmental timing by regulating embryonic progression.
PRR9 protein condensation modulates plant circadian clock speed in response to high temperatures, ensuring temperature compensation.
Senescent cells survive by forming adhesion-dependent fragments called SCAFs that contain damaged organelles and rupture to release pro-inflammatory proteins.
Nodal/Smad2 signaling maintains embryonic diapause in mice by repressing lipid storage pathways in blastocysts.
Pax7 is expressed in multiple skeletal muscle cell types, not exclusively in muscle stem cells, challenging its role as a definitive marker.
VHL-HIF signaling axis with HIF1α and HIF2α directs iNKT cell survival and differentiation during thymic development.
Senescent cells shed large cytoplasmic fragments that enhance their survival and may facilitate communication with neighboring cells.
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