mSystemsJClub
Differential impacts of early, extended-spectrum, and last-resort β-lactams on manure-derived microbiomes and resistomes in an in vitro model.
mSystems · · Journal Article · Open access
Davidovich, Blum + 1 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Extended-spectrum and last-resort β-lactams cause more pronounced shifts in manure-derived microbiomes and resistomes than ampicillin in an in vitro model.
- Why it matters: Understanding how different antibiotics influence microbial communities and resistance gene dissemination is vital for managing environmental AMR spread and clinical resistance.
- What they did: The study applied an enrichment approach to poultry manure, exposing microbial communities to cefotaxime, meropenem, ampicillin, and controls, then analyzed changes in diversity, resistome, and mobilome profiles.
- The result: Cefotaxime and meropenem induced stronger and more specific shifts in community composition and ARG profiles, highlighting how antibiotic spectrum influences microbiome and resistance gene dynamics.
The findingWhy it mattersWhat they didThe result
- Open access