Genome architecture drives antifungal resistance in Candida auris.

Segmental duplication and supernumerary chromosomes are linked to antifungal resistance in Candida auris, expanding the genetic mechanisms beyond mutations.

• Why it matters: Understanding all genetic factors behind antifungal resistance is crucial for developing effective treatments against emerging pathogens like Candida auris, which pose significant health risks.
• What they did: Narayanan et al. analyzed the genome architecture of Candida auris, highlighting the role of structural variations such as segmental duplication and supernumerary chromosomes in resistance.
• The result: The findings suggest that genome structure contributes to antifungal resistance, challenging the traditional mutation-focused view and broadening potential targets for intervention.