Multipath interaction network of annexin A2: multifaceted regulation and translational perspectives in neurological diseases.

Annexin A2 operates within a multipath interaction network influencing neurological diseases, with many signaling outputs arising from membrane trafficking and receptor organization.

• Why it matters: Understanding how Anxa2's broad functions contribute to neurological diseases is crucial for developing targeted therapies, as its diverse roles complicate direct intervention strategies.
• What they did: The study reviews evidence linking Anxa2 to key signaling pathways such as PI3K/AKT, MAPK/ERK, NF-κB, and TGF-β, emphasizing its indirect influence through membrane and cellular state changes.
• The result: This network-based perspective suggests that modulating Anxa2 in a disease-, cell-, and interaction-specific manner could improve its potential as a biomarker and therapeutic target in neurological conditions.