Boosting CAR T cell efficacy in cancer with metabolic insights from design to diet.

Metabolic factors influenced by CAR design, manufacturing, and host diet are key to improving CAR T cell efficacy against solid tumors.

• Why it matters: Current CAR T cell therapies face challenges in achieving durable responses, especially in solid tumors, partly due to metabolic limitations affecting T cell function and persistence.
• What they did: The review analyzes how metabolic profiles are shaped by co-stimulatory domains, manufacturing conditions, and host diet, emphasizing the need for standardized metabolic parameters in clinical protocols.
• The result: Integrating metabolic and dietary strategies offers a promising approach to overcoming barriers in solid tumor treatment, potentially enabling more durable and effective CAR T cell therapies.