Cellular senescence: six decades of discovery and reinvention.

Cellular senescence is now recognized as a complex stress-response program that actively influences tissue homeostasis, aging, and disease, with causal roles demonstrated in mouse models.

• Why it matters: Understanding the evolving conceptual framework of senescence is crucial for developing targeted therapies for age-related diseases and tissue repair, addressing a significant health challenge.
• What they did: The authors review six decades of discoveries, including molecular mechanisms, biomarkers, and genetic models, highlighting technological advances like single-cell analysis and precision biomarkers.
• The result: This synthesis underscores how emerging tools and targeted interventions may shape future senescence research and therapeutic strategies, advancing clinical applications.