Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection.

Migratory dermal γδ T cells activated via IL-1R regulate lung immune responses and tissue damage during helminth infection.

• Why it matters: Understanding how immune responses are communicated across tissues during helminth infection is crucial for developing strategies to prevent tissue damage and improve host protection.
• What they did: The study used a percutaneous infection model with Nippostrongylus brasiliensis and found that dermal γδ T cells become activated through IL-1R, then migrate from skin to lung tissue, influencing immune responses.
• The result: Blocking γδ T cell migration reduces early IL-17 production in the lungs, increases IFN-γ response, and results in greater lung tissue damage, highlighting a skin-lung immune axis.