Right size, right time: The Hippo-IGF2 axis calibrates liver growth and regeneration.

Hippo-controlled Igf2 expression is linked to postnatal liver growth and regeneration, highlighting a key regulatory mechanism.

• Why it matters: Understanding how organ size is precisely regulated after birth is crucial for developing therapies for liver diseases and regenerative medicine.
• What they did: Zhong et al. investigated the connection between Hippo signaling and Igf2 expression, focusing on their roles in liver growth and regeneration, based on mechanistic insights.
• The result: The study reveals that Hippo signaling controls Igf2 expression, which in turn calibrates liver growth and regeneration during postnatal development.