Risk factor analysis for early and late invasive Candida infections in solid organ transplant recipients.

Posttransplant Candida colonization and surgical complications are identified as key risk factors for invasive candidiasis in solid organ transplant recipients within the first year.

• Why it matters: Invasive candidiasis poses a significant threat to solid organ transplant recipients, yet data on specific risk factors during this period are limited, hindering targeted prevention strategies.
• What they did: A large multicenter cohort study within the Swiss Transplant Cohort identified 90 early and 48 late IC episodes among 4755 and 4519 recipients, analyzing risk factors through multivariable models.
• The result: Candida colonization and surgical complications significantly increase early and late IC risk, respectively, informing the need for tailored prophylactic approaches in high-risk patients.