Beyond BMI: The diet-microbiome context of the obesity paradox.

Anti-PD-1 sensitivity in diverse mouse models is more closely linked to the diet-microbiome-metabolite ecosystem than to obesity-associated metabolic dysfunction.

• Why it matters: BMI is an incomplete proxy for host biology, limiting its usefulness in predicting treatment responses and understanding obesity-related health outcomes.
• What they did: Desharnais et al. analyzed multiple mouse models, focusing on the diet-microbiome-metabolite ecosystem to explore factors influencing anti-PD-1 sensitivity.
• The result: Their findings suggest strategies to enhance anti-PD-1 efficacy without inducing obesity, emphasizing the importance of the diet-microbiome-metabolite ecosystem over BMI.