Cell atlas of the developing human meninges reveals a dura-like nature of meningiomas.

Meningiomas resemble dura-lineage cells and may originate from dura-like tissue, as shown by transcriptomic similarity in human fetal meninges.

• Why it matters: Understanding the cellular origin of meningiomas is crucial because current treatments are limited, especially for tumors resistant to local therapies, and molecular evidence has been lacking.
• What they did: The study generated a comprehensive single-cell and spatial transcriptomic atlas of human fetal meninges at postconceptional weeks 5-13, revealing developmental features and gene expression patterns.
• The result: Findings suggest that meningioma cells share transcriptional features with dura-lineage cells and express common driver genes, supporting the hypothesis that meningiomas may originate from dura-like tissue.