Integrated multi-omics analysis identifies PPAR signaling network associations with metabolic-immune dysregulation and intestinal injury in PDCoV-infected piglets.

Integrated multi-omics analysis reveals PPAR signaling network associations with lipid metabolism alterations and intestinal injury in PDCoV-infected piglets.

• Why it matters: Understanding host response networks in PDCoV infection is crucial because the disease causes severe diarrhea and high mortality in piglets and can infect human cells, yet these networks remain poorly characterized.
• What they did: Researchers performed combined transcriptomic, proteomic, and metabolomic profiling of jejunal tissues from PDCoV-infected piglets, identifying key pathways including PPAR signaling with specific gene regulation patterns.
• The result: Findings suggest PDCoV infection modulates the PPAR pathway, potentially contributing to lipid resource reallocation and inflammation, with implications for therapeutic targeting and parallels to SARS-CoV-2-related metabolic-immune dysregulation.