Prognostic Value of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve From a Large Nationwide Cohort.

Coronary computed tomography angiography-derived fractional flow reserve (FFR-CT) predicts future cardiovascular events, with lower values linked to higher risk in a large nationwide cohort.

• Why it matters: Understanding the prognostic value of FFR-CT can improve risk stratification in stable coronary artery disease, addressing limitations of previous small or short-term studies.
• What they did: Researchers analyzed 7,836 patients across England from 2017 to 2020, relating FFR-CT measurements to myocardial infarction, cardiovascular death, all-cause death, and revascularization over three years, dividing FFR-CT into subgroups.
• The result: Lower FFR-CT values were associated with increased hazard ratios for adverse outcomes, with an optimal risk cutoff at 0.67, and FFR-CT improved prediction beyond traditional risk factors and stenosis severity.