Mito-nuclear incompatibility disrupts acyl-CoA oxidase 1/acyl-CoA oxidase 3-mediated mitochondria-peroxisome metabolic coordination in black soldier flies.

Mito-nuclear incompatibility in black soldier flies disrupts mitochondrial function and peroxisome-mediated fatty acid metabolism, involving ACOX1 and ACOX3 genes.

• Why it matters: Understanding how genomic incompatibilities affect cellular organelle coordination is crucial for insights into organismal fitness and metabolic regulation, especially in insects.
• What they did: The study introduced heterologous mitochondrial genomes into a common nuclear background in Hermetia illucens and combined genomic, transcriptomic, metabolomic, and functional analyses to examine effects.
• The result: Disruption of mitochondrial and peroxisomal functions led to energy deficiency, oxidative stress, developmental delays, and reproductive issues, with ACOX gene expression playing a key role in metabolic dysregulation.