Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity.

Alox15 is essential for M2 macrophages to trap and kill helminths by restraining glycolysis during helminth immunity.

• Why it matters: Understanding how macrophages exert their anti-helminth effects is crucial for developing better treatments for parasitic infections and tissue repair strategies, yet the metabolic regulation involved remains unclear.
• What they did: The study examined Alox15's role in macrophage polarization, using knockout models to assess M2 function and metabolic activity, focusing on glycolysis and lipid signaling pathways.
• The result: Loss of Alox15 impairs helminth trapping and killing despite normal M2 marker expression, due to increased glycolysis and pro-inflammatory responses, which can be normalized by PPAR-δ activation.