Dysregulated AKT signaling in osteosarcoma enhances dependency on EP300, with sensitivity to EP300 degradation linked to AKT activation and relocalization of epigenetic regulators.
Journal of Experimental Medicine
Rockefeller University Press · Immunology & Inflammation · ISSN 0022-1007, 1540-9538
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A Crohn's disease risk allele linked to increased SKAP2 expression in T cells modulates adhesion and migration balance.
Accumulation of α-synuclein in CSF and dura mater is linked to CNS clearance deficits in Parkinson's disease patients.
Blocking Fc receptor-mediated neutrophil activation with one-armed antibodies reduces renal injury in MPO-ANCA vasculitis models.
Autoantibody-induced neutrophil-epithelial niches are linked to kidney injury in MPO-associated glomerulonephritis, with anti-MPO antibodies recognizing multiple epitopes enhancing neutrophil activation.
Macrophages act as programmable integrators of disease tolerance, with age-related reconfiguration of tolerance networks affecting tissue protection and pathology.
Combining multiple strategies to convert cold tumors into hot tumors is necessary for durable antitumor immune responses.
Exogenous nitric oxide shows potential as an anti-infective agent, especially for pulmonary infections like tuberculosis, with evidence supporting its safety and efficacy at higher doses.
Launching an independent research laboratory requires practical strategies to build a resilient team and coherent program amid uncertainty and limited resources.
HIV-1 reservoir cells are more visible and vulnerable to immune responses than previously thought, challenging the traditional latency model of persistence.
Biallelic loss-of-function variants in PTPN6 are linked to early-onset anemia and severe inflammatory lung disease, including ARDS, in seven children from five families.
Inherited RORγT deficiency causes near-complete depletion of innate-like adaptive T cells and predisposes patients to mycobacterial disease and CMC across diverse ancestries.
CAMKV kinase, a MYCN/MYC-regulated effector with intrinsic kinase activity, is essential for neuroblastoma growth and correlates with advanced disease and poor survival.
Long-lived naive CD8 T cells acquire tonic TCR signaling during homeostasis, leading to their differentiation into functionally superior effectors.
Vps4B facilitates continuous caspase-1 recruitment and activation at the ASC speck, promoting inflammasome function and host defense in vivo.
C3 and CD47 mediate elimination of supernumerary proprioceptive synapses in developing spinal circuits, ensuring proper motor control in mammals.
Natural microbiota-based mouse models more accurately mimic human physiological responses than conventional laboratory mice.
Alox15 is essential for M2 macrophages to trap and kill helminths by restraining glycolysis during helminth immunity.
Qdenga vaccine elicits serotype-skewed antibody responses with only 8% of DENV-naïve adults developing tetravalent neutralization, mainly targeting DENV-2.
Naïve CD8 T cells marked by IL-18Rα, CD73, and CXCR3 exhibit superior persistence and effector/memory responses, enhancing protection.
Autoantibodies neutralizing type I IFNs are linked to approximately 5% of adult herpes simplex encephalitis cases.
Borrelia burgdorferi causes rapid disruption of gut barrier functions and impairs microbiota-antibody interactions in infected mice and humans.
Vagal neuroimmune circuits are key mediators of immune responses, with vagal sensory neurons detecting inflammatory cues and modulating immunity in health and disease.
UA-30 delays systemic aging and improves muscle function in naturally aged mice by inhibiting RalA signaling, reducing fibrosis, and extending lifespan.
Silencing TNFR1 on tumor cells reduces immune escape by decreasing MDSC recruitment, impairing tumor engraftment in immunocompetent hosts.
GABPA directly regulates STING transcription and amplifies antiviral and inflammatory responses via IKKε-mediated phosphorylation in macrophages.
Deletion of Helios in Tregs causes adipose tissue dysfunction, systemic immune activation, and metabolic disturbances in mice.
Upper respiratory tract CD8+ tissue-resident memory T cells alone can prevent viral transmission in mice, highlighting their critical protective role.
Broadening CSP regions targeted in malaria vaccines enhances immune responses and protection, with a 2-fold increase in antibody diversity and efficacy.
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3