Generation of TWO iPSC lines (CRICKi025-A and CRICKi026-A) from healthy donor bone marrow mesenchymal stromal cells.

Two human iPSC lines reprogrammed from adult bone marrow MSCs are genomically stable and can differentiate into the three germ layers.

• Why it matters: Primary bone marrow MSCs are rare, heterogeneous, and limited in ex-vivo expansion, which restricts their research and therapeutic applications. Developing stable iPSC lines from these cells can overcome these limitations.
• What they did: Researchers reprogrammed MSCs from healthy donor bone marrow using non-integrating Sendai virus vectors to generate two iPSC lines, CRICKi025-A and CRICKi026-A, which exhibit pluripotency and stability.
• The result: These iPSC lines serve as well-characterized resources for generating MSCs, potentially enabling improved modeling and regenerative strategies involving bone marrow-derived cells.