Fucosylated hemocyanin regulates ER stress to enhance shrimp antibacterial immunity.

Fucosylated hemocyanin enhances shrimp antibacterial immunity by regulating ER stress and AMP production, reducing Vibrio parahaemolyticus loads in vivo.

• Why it matters: Understanding how PTMs like fucosylation influence immune signaling in crustaceans fills a critical knowledge gap, potentially leading to improved disease management strategies.
• What they did: Researchers identified that highly fucosylated Pv HMC interacts with Pv Bip, promoting ER stress responses and AMP transcription; these effects were confirmed through pull-down assays and functional tests involving ER stress modulation.
• The result: High-Fuc-Pv HMC decreased Vibrio loads and increased shrimp survival, while reduced fucosylation or ER stress inhibition weakened these effects, revealing a novel intracellular immune regulatory mechanism.