An integrated lifestyle intervention for mitigation of adverse effects associated with androgen deprivation therapy for prostate cancer (STAMINA): a multicentre, randomised trial.

The STAMINA lifestyle intervention significantly improves quality of life and reduces fatigue in men with prostate cancer on ADT, with FACT-P scores increasing by 4.5 points.

• Why it matters: Adverse effects of androgen deprivation therapy (ADT) are common and impact patients' well-being, yet supervised exercise is rarely integrated into standard care, highlighting a gap in supportive treatment options.
• What they did: A multicentre, randomised trial involving 700 men across 15 UK NHS trusts tested the STAMINA intervention, which included supervised aerobic and resistance exercise, dietary advice, behavioral support, and gym membership, compared to Optimised Usual Care.
• The result: The intervention led to statistically significant improvements in FACT-P and FACIT-F scores (p=0.0004 and p=0.0068, respectively), demonstrating its potential for implementation in NHS settings to mitigate ADT-related adverse effects.