Structure and function of the centromere and inner kinetochore.

Recent advances reveal the complete structure and function of the inner kinetochore and the organization of centromeric chromatin, enhancing understanding of chromosome segregation.

• Why it matters: Accurate chromosome segregation is vital for cell division, and understanding kinetochore and centromere structure addresses gaps in knowledge about how chromosomes are correctly distributed to daughter cells.
• What they did: The review discusses recent findings on the structure and function of the inner kinetochore, as well as the sequence and 2D and 3D organization of centromeric chromatin, highlighting implications for assembly and function.
• The result: These insights improve understanding of kinetochore assembly and function, and they identify key questions that will guide future research in the field.