Generation of three induced pluripotent stem cell lines from an immune checkpoint inhibitor-induced myocarditis patient and controls.

Three induced pluripotent stem cell lines were generated from an immune checkpoint inhibitor-induced myocarditis patient, an ICI-treated patient without myocarditis, and a healthy donor.

• Why it matters: Understanding the mechanisms of immune checkpoint inhibitor-associated myocarditis (ICIM) is limited by the lack of suitable human models, which hampers progress in developing treatments for this potentially fatal disease.
• What they did: Researchers created three iPSC lines that display typical pluripotent morphology, express pluripotency markers, maintain normal karyotypes, and can differentiate into all three germ layers, from a patient with ICIM, an ICI-treated patient without myocarditis, and a healthy individual.
• The result: These iPSC lines provide a valuable platform for studying ICIM mechanisms and discovering therapeutic strategies, addressing a critical gap in disease modeling.