Ozone induced pulmonary injury and respiratory dysfunction: Evidence, underlying mechanism and target investigation.

Ferroptosis is a key driver of ozone-induced lung injury, with taurine supplementation significantly mitigating respiratory dysfunction and histological damage in mice.

• Why it matters: Understanding the mechanisms behind ozone-related respiratory harm is crucial for developing effective therapies, as current knowledge on mediators and targets remains limited.
• What they did: The study used integrated proteomic and metabolomic analyses to examine ozone's effects in mice lungs, focusing on ferroptosis markers and metabolic pathways, and tested taurine's protective role.
• The result: Taurine supplementation markedly improved lung function, reduced inflammation, and inhibited ferroptosis, highlighting its potential as a therapeutic agent against ozone-induced respiratory injury.