The bioproduction of prodigiosin: A comprehensive review on the microbial biosynthesis, regulatory mechanism and cost-effective fermentation strategies.

Recent advances have revealed novel wild-type producers and regulatory mechanisms that could enhance prodigiosin biosynthesis and structural diversity.

• Why it matters: Understanding these biosynthetic pathways and regulatory networks is crucial for optimizing production and expanding applications in medicine, industry, and ecology.
• What they did: The review summarizes progress on PG structure-function relationships, gene clusters, transcriptional regulation, and metabolic engineering, along with fermentation strategies to improve yields and reduce costs.
• The result: These insights lay a theoretical foundation for designing efficient bioprocesses for PG and derivatives, enabling their future development across multiple sectors.