medRxivJClub
A prospective case-control study of the gut bacteriome and mycobiome in glioblastoma
medRxiv · · Preprint · Open access
Herz, Schmid + 13 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Fungal diversity is significantly lower in the gut of glioblastoma patients compared to healthy controls, with a p-value less than 0.001.
- Why it matters: Understanding the gut microbiome's role in glioblastoma could reveal new insights into tumor biology and potential therapeutic targets, addressing a gap in human data.
- What they did: The study sequenced bacterial and fungal communities from rectal swabs of 23 glioblastoma patients and 23 controls, analyzing diversity and community structure.
- The result: Lower fungal diversity was observed in patients, while bacterial diversity and overall community structure did not differ; a higher intratumoral myeloid cell proportion was linked to longer survival.
The findingWhy it mattersWhat they didThe result
- Open access