Guanine nucleotide depletion via IMPDH2 inhibition suppresses pancreatic cancer and enhances KRAS inhibitor efficacy, with depletion being irreversible and independent of KRAS pathways.
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- 5 cites
Biochemical and Molecular Research
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A small molecule inhibitor, V20, was identified that modulates SAL enzyme activity, increasing PAP levels and stress tolerance in Arabidopsis thaliana.
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- 2 cites
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- Nature161
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- Science141
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- J Exp Bot108
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
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