Inhibiting p65 autopalmitoylation with licochalcone D reduces NF-κB activity by blocking its nuclear localization and complex formation.
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Signaling Pathways in Disease
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KRASG12R pancreatic cancer cells develop resistance to daraxonrasib via EGFR/RASWT signaling, enabling effective trametinib-based therapy and extending patient survival to 40 months.
- Open access
A small molecule inhibitor, V20, was identified that modulates SAL enzyme activity, increasing PAP levels and stress tolerance in Arabidopsis thaliana.
- Open access
- 2 cites
KRASG12R mutants in pancreatic cancer develop resistance to daraxonrasib via EGFR/RASWT signaling, enabling effective trametinib-based therapy and extended patient survival.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
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- Alzheimer's disease research and treatments3
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