Adenosine and Purinergic Signaling

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Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity
bioRxiv · 9 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.25.655979
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Exploiting a purine imbalance to target KRAS mutant pancreatic adenocarcinomas.
Gut · 7 Oct 2026 · Journal Article
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A double endocrine-disrupting effect of PFAS on intra- and extra-thyroid targets: inhibition of iodide uptake and interference with MCT8-mediated T3 transport in vitro.
Environmental pollution · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42392299
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NAD(+) depletion by catalytic TIR domains triggers a distinct form of regulated necrosis in mammalian cells.
Proceedings of the National Academy of Sciences · 22 Sept 2026 · Journal Article
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https://jclub.com.au/a/42752230
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Loss of the Ap(4)A hydrolase YqeK impairs stress adaptation and virulence gene expression in Staphylococcus aureus.
Journal of bacteriology · 17 Sept 2026 · Journal Article
Loss of YqeK in Staphylococcus aureus causes a 1,000-fold increase in Ap 4 N levels and impairs stress resistance and virulence gene expression.
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https://jclub.com.au/a/42622426
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CD73 disruption with tumor-specific CRISPR/Cas9 nanoparticles reduces adenosine-mediated immunosuppression and amplifies response to chemotherapy.
Nature Communications · 8 Sept 2026 · Journal Article
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Application of nucleoside analogue labelling to study the cell cycle of xenografted PDAC cell lines in the chorioallantoic membrane model.
bioRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.09.675135
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Whole-organism screening in a zebrafish model of CLN2 disease identifies pregnenolone as a modulator of lysosomal functions with anti-epileptic properties
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.26.670480
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Drugging endosomal flux.
Nature Chemical Biology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42432344
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