Adipokines, Inflammation, and Metabolic Diseases

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Validation of targets linked to weight gain in C57BL/6 mice and translational aspects in humans.
Proceedings of the National Academy of Sciences · 21 Oct 2026 · Journal Article
Tissue-specific inhibition of Nova1, Mchr1, Nr1i3, and Ahr in mice reduces susceptibility to high-fat diet–induced obesity and glucose intolerance, highlighting complex genetic influences.
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Author Correction: Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis.
Nature Communications · 21 Oct 2026 · Published Erratum
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The Role of Macronutrient Composition in Semipurified Diets in Shaping Distinct Obesity Phenotypes: Evidence for Hepatic Oxidative Stress Involvement
bioRxiv · 14 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.17.665389
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Ablation of hematopoietic stem cell derived adipocytes reduces tumor burden in syngeneic mouse models of high-grade serous carcinoma
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.09.19.613924
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The interplay between the microbiome and immune cells in metabolic homeostasis and disease.
Cell Metabolism · 6 Oct 2026 · Review
Microbiome-derived metabolites modulate immune cells through molecular pathways, influencing metabolic health or chronic inflammation linked to cardiometabolic diseases.
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https://jclub.com.au/a/42372727
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Aged white adipose tissue is rejuvenated in a young host through thermogenic remodeling of mature adipocytes
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.28.696721
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Microglial protein kinase CK2 prevents obesity in mice potentially through NLRP3 inflammasome activation.
Nature Communications · 22 Sept 2026 · Journal Article
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https://jclub.com.au/a/42907441
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FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology.
Cell Metabolism · 22 Sept 2026 · Published Erratum
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https://jclub.com.au/a/42772286
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Transient activation of ciliary CCR2 signaling promotes the initiation of adipogenesis.
Nature Communications · 17 Sept 2026 · Journal Article
Transient activation of ciliary CCR2 signaling in preadipocytes initiates adipogenesis through ERK-dependent pathways.
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https://jclub.com.au/a/42893979
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Abnormal glucose metabolism and muscle mass decline by bisphenol A or bisphenol S in skeletal muscle of male mice:inhibition of mitophagy by downregulation of the ERα/AMPK/ULK1 pathway.
Environmental research · 15 Sept 2026 · Journal Article
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https://jclub.com.au/a/42571834
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ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance.
Cell Reports · 15 Sept 2026 · Journal Article
ENPP1 prevents extracellular cGAMP accumulation in brown adipose tissue, reducing insulin resistance and obesity in high-fat diet conditions.
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https://jclub.com.au/a/42743059
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Gut microbiota composition outperforms chronological age in predicting systemic inflammation and incident disease risk.
Nature Communications · 8 Sept 2026 · Journal Article
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https://jclub.com.au/a/42844264
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Associations of Metabolic Vulnerability Index with Cardiometabolic Diseases, Multimorbidity, and All-cause Mortality
medRxiv · 4 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.09.26345939
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Brown fat protects against hepatic oxidative stress by remodeling the circulating metabolome.
Cell Metabolism · 1 Sept 2026 · Journal Article
Brown adipose tissue reduces hepatic oxidative stress by releasing 3-hydroxystearic acid, a cold-induced metabolite that modulates liver mitochondrial function.
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