NeoBridge achieves a 0.82 AUC-ROC in predicting neoantigens in pancreatic ductal adenocarcinoma, surpassing established tools and demonstrating strong cross-cancer generalization.
Cell Genomics
Elsevier BV · Genomics & Bioinformatics · ISSN 2666-979X
- Impact (2-yr)
- 9.4
- h-index
- 59
- Open access
- 100%
- Works
- 721
- Papers this month
- 22
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A pangenomic method creates a comprehensive somatic variant resource with over 6 million SNVs and 49,000 structural variations from HapMap mixtures.
Detection of low-allele-fraction mosaic mutations with VAFs above 2% achieves nearly 80% sensitivity and precision at 300× sequencing depth across multiple centers.
Deep learning reveals that low-affinity pioneer factor binding sites contribute to chromatin opening in mouse embryonic stem cells.
MOSHPIT, a QIIME 2-based software, enables streamlined, reproducible metagenome analysis with integrated provenance tracking and validation, suitable for all expertise levels.
Alignment of 20 complete great ape genomes reveals 1,596 rapidly evolved human-specific regions enriched in disease loci and active in brain and heart development.
Low-affinity transcription-factor motifs significantly influence chromatin accessibility by cooperating through intra-nucleosomal soft syntax, expanding regulatory potential in mouse embryonic stem cells.
Cell-type-specific damage scores accurately identify disease progression in kidney and liver diseases across multiple datasets, with PDS and HDS revealing damage thresholds and pathways.
Super-enhancer hubs are rare, nonspecific, and neither necessary nor sufficient for transcriptional bursting in mouse embryonic stem cells.
PUS7's mRNA pseudouridylation is driven by specific RNA sequence, structure, and cell-type features, with USUAG being a key recognition motif.
Members of the Cell Genomics board provided reflections on 5 years of the journal, highlighting key insights and perspectives.
Contributors to Cell Genomics report diverse research focuses and anticipate significant future developments in their fields over the next five years.
Choice of phenotype scale can explain up to 45% of polygenic score × sex interactions in UK Biobank phenotypes.
An optimized CRISPRi-Cas9 library called Katsano improves gene targeting efficiency and specificity based on extensive dataset analysis.
Distinct architectures of midbody remnants in somatic mitosis and oocyte meiosis are linked to their functions and clinical applications.
Twelve Chinese genomics researchers reflect on their findings, publishing, community, and future directions over five years of Cell Genomics.
Institut Pasteur de Côte d'Ivoire established genomic surveillance capacity during COVID-19, serving as a strategic blueprint for Africa's health resilience.
A single-cell and spatial transcriptomic atlas across 10 vertebrate species reveals that cellular evolution in the gastrointestinal system is driven by gene repurposing and de novo gene emergence over 500 million years.
RandomReadsMG generates terabase-scale metagenomic datasets within 6 hours, supporting realistic benchmarking and experimental design at large scale.
Response eQTLs identified in differentiating human iPSC cultures exposed to environmental substances share properties with disease-associated loci, highlighting context-dependent regulation.
Conserved and human-specific cis-regulatory elements in the mammalian brain are enriched for neuropsychiatric GWAS risk, with neurodegenerative risk linked only to conserved elements.
Pre-diagnosis plasma cell-free DNA methylation signatures predict prostate and breast cancer risk up to nine years before diagnosis, with hazard ratios of 3.55 and 2.3 respectively.
Interspecies comparison of single-cell RNA sequencing identifies conserved signature genes that robustly define homologous bone marrow cell types across four mouse species.
Paternal de novo mutation risk for developmental disorders is mainly influenced by age-related mutation accumulation and selection, with early mosaicism contributing to about 8% of cases.
Cell-type fine-mapping reveals 79 independent cellular mechanisms explaining 39% of trait heritability across 63 GWASs.
Over half of public RNA-seq samples originate from US institutions, with 90% from high-income countries, yet only 3% include population descriptors, revealing significant bias.
Single-cell transcriptomics reveals cell-type-specific immune responses to stress hormones, identifying signatures linked to stress-related diseases in humans.
PlantCAD2, a DNA foundation model, accurately interprets genomes across over 2,000 flowering plant species, advancing plant genomics research.
Base editing has achieved significant clinical progress, with promising applications in treating over half of pathogenic genetic variants, including sickle cell disease and hypercholesterolemia.
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
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- Dementia and Cognitive Impairment Research3