Pharmacologic Treatments for Females With Menopausal Vasomotor Symptoms: A Clinical Guideline From the American College of Physicians.

ACP recommends estrogen-based treatments as first-line options for females with menopausal vasomotor symptoms, with high-certainty evidence supporting their use.

• Why it matters: Effective management of menopausal vasomotor symptoms is essential for improving quality of life, but optimal pharmacologic options require clear guidance based on evidence and patient preferences.
• What they did: The guideline is based on systematic reviews using the GRADE approach and recommends estrogen with progestogen for women with a uterus and estrogen alone for women without a uterus, supported by high-certainty evidence.
• The result: This guidance enables clinicians to tailor treatment choices through informed decision-making, considering benefits, harms, contraindications, and patient values, thereby improving personalized care.