Formulations containing co-biotic compounds mediate microbiome function and composition without increased gas production in an ex vivo gastrointestinal model.

Formulations containing co-biotic compounds significantly increase microbiome-derived metabolites and beneficial taxa without raising gas production in an ex vivo human gut model.

• Why it matters: Understanding how co-biotic formulations influence gut microbiome function is crucial for developing targeted interventions that improve host health without adverse effects like excess gas.
• What they did: The study tested three co-biotic formulations—DM-02, AM-02, and PM-02—on digested human gut samples from six healthy adults, measuring pH, SCFAs, gas, metagenomics, and metabolomics after 24-hour simulated colonic fermentation.
• The result: All formulations reduced pH, increased total SCFAs and specific metabolites, and enriched beneficial microbial pathways and taxa, demonstrating potential for microbiome modulation without increased gas production.