Solid-state nanopore sensing: the next workhorse of biophysical characterization.

Solid-state nanopores are poised to become essential tools for studying macromolecular superstructures in biological and synthetic systems.

• Why it matters: Understanding supramolecular chemistry is crucial for advancing biological research and developing new technologies, but current methods lack the versatility of nanopores.
• What they did: The authors highlight the advantages of solid-state nanopores, such as size tunability and functionalization, and discuss their potential in applications beyond sequencing, including drug screening and protein engineering.
• The result: Ongoing improvements in hardware and experimental design are expected to expand the use of solid-state nanopores, enabling new insights into complex biochemical systems and facilitating innovative applications.