The evolving landscape of drug targets.

The number of drug targets has expanded to 686 biomolecules modulated by 1,702 drugs over the past 25 years, reflecting a significant evolution in therapeutic options.

• Why it matters: Understanding how the drug target landscape has changed is crucial for advancing drug discovery and addressing diseases that previously lacked effective treatments.
• What they did: The authors mapped and quantified trends in the number and types of drug targets, analyzing data from the past 25 years to identify key shifts in the field.
• The result: This analysis highlights ongoing and future trends in target druggability, supporting the development of new therapeutic modalities and expanding treatment possibilities.