SwinePan for pig graph-based pangenome and multiomics data mining.

SwinePan reveals 185,759 structural variants and 117 million SNPs across 2,598 pigs from 35 breeds using a graph-based pangenome framework.

• Why it matters: Current reliance on a single linear reference genome limits the detection of genetic diversity and structural variants in pigs, hindering comprehensive genetic analysis and breeding efforts.
• What they did: The study developed SwinePan, a multiomics database built on a graph-based pangenome, integrating genomic, transcriptomic, and phenotypic data, and enabling GWAS, eQTL mapping, and colocalization analyses.
• The result: SwinePan facilitates identification of trait-associated loci and understanding of regulatory mechanisms, advancing pig genetics research and breeding strategies.