Mechanisms of key gut microbial metabolites: SCFAs, BAs, and TDMs.

Gut microbial metabolites SCFAs, BAs, and TDMs regulate host immunity, metabolism, and neural function through local and distant effects, impacting disease pathways.

• Why it matters: Understanding how these metabolites influence host health is crucial because disruptions in their pathways are linked to inflammatory diseases, neurodegeneration, and cancer, highlighting potential therapeutic targets.
• What they did: The review discusses the roles of SCFAs, BAs, and TDMs in various host contexts, analyzing their molecular mechanisms on target cells and exploring therapeutic implications of modulating these microbial pathways.
• The result: Elucidating these mechanisms may enable future clinical strategies to target microbial metabolites for treating inflammatory, neurodegenerative, and cancerous conditions.