Integrated transcriptomic and metabolomic dynamics reveal mechanisms of tobacco resistance to Phytophthora nicotianae.

Integrated transcriptomic and metabolomic analyses reveal that resistant tobacco cultivar 'Xiangyan 7' activates defense pathways, with 14,160 DEGs and 355 DAMs during P. nicotianae infection.

• Why it matters: Understanding the molecular mechanisms of tobacco resistance to Phytophthora nicotianae is crucial for developing durable disease-resistant crops and reducing yield losses caused by black shank disease.
• What they did: Researchers conducted time-course RNA-seq and metabolomic profiling on resistant and susceptible tobacco cultivars, identifying key genes, metabolites, and pathways involved in resistance, including 593 hub genes and multiple enriched pathways.
• The result: Findings highlight rapid activation of phenylpropanoid, flavonoid, and hormone signaling pathways in resistant tobacco, providing candidate genes and multi-omics resources to enhance black shank disease resistance.