Associations between aromatic amines and oxidative stress biomarkers among pregnant women in the San Francisco Bay Area of California.

Elevated aromatic amines are linked to increased oxidative stress biomarkers in pregnant women, with ΣAA associated with up to 0.25 unit increases in 8-iso-PGF2α.

• Why it matters: Understanding how environmental toxins like aromatic amines affect pregnancy outcomes is crucial, as oxidative stress is connected to adverse maternal and child health, yet little is known about this relationship.
• What they did: The study analyzed urine samples from 176 pregnant women, measuring 36 aromatic amines and four F2-isoprostanes, using regression models to assess associations between AAs and oxidative stress biomarkers.
• The result: Findings show most aromatic amines correlate with higher oxidative stress levels, suggesting AAs may contribute to pregnancy complications through oxidative mechanisms, informing future health risk assessments.