Intracellular Pseudomonas aeruginosa: internalization and survival.

Pseudomonas aeruginosa can survive intracellularly in human tissues, potentially forming reservoirs that contribute to chronic infections and relapse.

• Why it matters: Understanding its intracellular survival is crucial because it may explain persistent infections and resistance to certain antibiotics, posing challenges for treatment.
• What they did: The authors review how P. aeruginosa interacts with eukaryotic cells and examine the role of its protein secretion systems in establishing an intracellular niche, based on existing literature.
• The result: This work highlights the potential for intracellular reservoirs of P. aeruginosa to contribute to chronic infection and relapse, emphasizing the need for further research into its intracellular life cycle.