Ana1/Cep295 regulates centriole elongation via Cep135 and microtubules.

Ana1/Cep295 promotes centriole elongation in fly spermatocytes through interactions with Cep135 and microtubules, contributing to overelongation.

• Why it matters: Understanding how centrioles elongate is crucial because they are essential for centrosome and cilium formation, yet the mechanisms behind their dramatic elongation remain unclear.
• What they did: The study examined Ana1's role in centriole length regulation by investigating its interactions with Cep135 and microtubules, demonstrating that Ana1 directly binds Cep135 and bundles microtubules in vitro.
• The result: Both interactions contribute to centriole overelongation, revealing that Ana1 influences centriole elongation through multiple mechanisms involving distinct centriolar components during fly spermatogenesis.