SARS-CoV-2 and COVID-19 Research

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Moved, week to 22 Oct 2026: 1
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FDA Approves Updated COVID-19 Vaccines for 2026-2027.
JAMA · 20 Oct 2026 · Journal Article
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Latest in SARS-CoV-2 and COVID-19 Research

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Structure-Activity Relationship Studies Towards Analogues of Pleconaril as Novel Enterovirus-D68 Capsid-Targeting Antivirals
bioRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.08.668114
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Changing COVID-19 vaccine eligibility could reshape disease burden for all
medRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.27.26351870
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Acute infection as a driver of chronic diseases and the unsung benefits of vaccination.
Nature Microbiology · 16 Oct 2026 · Journal Article
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https://jclub.com.au/a/42888287
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Immunogenicity and Structure of a Stabilized HIV -1 clade C Env from a Pediatric Elite neutralizer in Complex with an Autologous bnAb
bioRxiv · 9 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.26.649701
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Determinants of human versus mosquito cell entry by the Chikungunya virus envelope proteins
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.25.672233
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Male and female mice achieve equivalent protection against heterologous SARS-CoV-2 infection through divergent immune mechanisms
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.28.755090
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The pharmacokinetics, bio-distribution and therapeutic efficacy of a trimeric nanobody against SARS-CoV-2 in the golden Syrian hamster COVID-19 model
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.17.694727
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A Monoclonal Antibody Panel to Track Antigenic Evolution of SARS-CoV-2 JN.1 Subvariants
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.29.728770
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Metatranscriptomics reveals diverse microbial communities in PCR-negative severe acute respiratory infections
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.19.712874
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Structure-guided vaccination elicits broadly neutralizing antibodies targeting the HIV-1 silent face
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.30.755568
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The changing face of UK academic drug screening in the past decade.
Nature Reviews Drug Discovery · 1 Oct 2026 · Letter
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vartracker: an end-to-end tool for pathogen longitudinal variant analysis and visualisation
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.06.723370
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Genetic variation in HLA, IGKV, and HHEX loci influences mRNA vaccine-induced humoral protection against COVID-19.
Cell Reports · 29 Sept 2026 · Journal Article
Genetic variation in HLA, IGKV, and HHEX loci significantly influences COVID-19 vaccine-induced neutralizing antibody responses and protection, with HLA linked to reduced breakthrough infections.
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https://jclub.com.au/a/42814572
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Integrated analysis of COVID-19 multi-omics data for eQTLs reveals genetic mechanisms underlying disease severity
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.12.18.629144
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Nsp3 Ubl1-orchestrated dephosphorylation of N protein promotes coronaviral subgenomic RNA synthesis
bioRxiv · 26 Sept 2026 · Preprint
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Rethinking seasonal COVID-19 vaccination in the endemic era: summer timing, eligibility, and frequency in the United States
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363810
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Direct and indirect effects of COVID-19 on infant bronchiolitis: a population-wide registry study from Northern Italy
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363663
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Structural insights into an aptainhibitor of the SARS-CoV-2 E protein using molecular docking, molecular dynamics, and biophysical analyses.
Molecular therapy. Nucleic acids · 23 Sept 2026 · Journal Article
Apt-E-36-3, a 30-mer DNA aptainhibitor, binds the SARS-CoV-2 E protein with nanomolar affinity and blocks its oligomerization, offering a potential therapeutic approach.
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https://jclub.com.au/a/42890159
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Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules
bioRxiv · 21 Sept 2026 · Preprint
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Combination of live-attenuated and adenovirus-based vaccines provides immediate and durable protection against Yersinia pestis in mice.
Molecular therapy. Nucleic acids · 17 Sept 2026 · Journal Article
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https://jclub.com.au/a/42892921
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Mutational constraints on RSV F and its neutralization by antibodies.
Nature · 16 Sept 2026 · Journal Article
Mutations in RSV F protein influence antibody neutralization, with resistance mutations emerging sporadically but remaining rare in circulating strains.
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https://jclub.com.au/a/42749798
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Convergent use of aminopeptidase N receptor by hedgehog merbecoviruses.
Nature Microbiology · 16 Sept 2026 · Journal Article
Hedgehog aminopeptidase N (APN) acts as a functional receptor for European and Asian hedgehog merbecoviruses, with a distinct binding mode revealed by cryo-EM analysis.
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Bridging the antiviral gap: A BAC-based non-infectious SARS-CoV-2 replicon reveals potent antisense gapmers.
Molecular therapy. Nucleic acids · 15 Sept 2026 · Journal Article
A BAC-based non-infectious SARS-CoV-2 replicon identified the M gene as a promising antisense target with an EC50 of 6.3 nM for antiviral development.
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https://jclub.com.au/a/42866432
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Deletion of the Envelope gene attenuates SARS-CoV-2 infection by altered Spike localization and increased cell-to-cell transmission
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.20.655126
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Divergent antibody-mediated population immunity to H5, H7 and H9 subtype potential pandemic influenza viruses
medRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.08.25335309
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Functional Characterization of SARS-CoV-2 3CLpro Variants
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.23.696280
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Rapid turnaround multiplex sequencing of SARS-CoV-2: comparing tiling amplicon protocol performance
medRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2021.12.28.21268461
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A divergent betacoronavirus with a functional furin cleavage site in South American bats.
Nature Communications · 5 Sept 2026 · Journal Article
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https://jclub.com.au/a/42838974
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Sex differences in vaccine-induced neuraminidase cross-recognition impact H5N1 dissemination to the lower respiratory tract in mice
bioRxiv · 4 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.26.728011
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A viral ORFeome.
Nature Methods · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42697991
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