Spatially resolved chromatin architectures in mammalian brain tissues.

Spatial Hi-C reveals 3D chromatin structures in mouse brain tissues with high fidelity and 10-μm resolution, linking chromatin topology to spatial microdomains.

• Why it matters: Understanding 3D genome organization within tissues is essential for decoding development and disease regulation, but current methods lack spatial context.
• What they did: The study applied spatial Hi-C to mouse embryos and brains, analyzing chromatin structures in cerebellum subclusters and adult cortex at near single-cell resolution, and observed a radial gradient of chromatin interactions.
• The result: Findings suggest spatial chromatin architecture correlates with anatomical features and neuronal maturity, enabling new insights into tissue-specific regulatory functions.